Publications
Generation of three isogenic human induced pluripotent stem cell lines from normal neonate skin fibroblasts. Stem Cell Res. 2024 Feb;74:103301.
Närvä E., Taskinen ME., Lilla S., Isomursu A., Pietilä M., Weltner J., Isola J., Sihto H., Joensuu H., Zanivan S., Norman J., Ivaska J. MASTL is enriched in cancerous and pluripotent stem cells and influences OCT1/OCT4 levels. iScience. May 25;25(6):104459, 2022.
Riivari S., Närvä E., Kangasniemi I., Willberg J., Närhi T. Epithelial Cell Attachment and Adhesion Protein Expression on Novel in Sol TiO2 Coated Zirconia and Titanium Alloy Surfaces. J Biomed Mater Res B Appl Biomater. Jun 22, 2022
Taskinen ME*, Närvä E*, Conway JRW, Hinojosa LS, Lilla S, Mai A, De Franceschi N, Elo LL, Grosse R, Zanivan S, Norman JC, Ivaska J. (2020). MASTL promotes cell contractility and motility through kinase-independent signaling. J Cell Biol. Jun 1;219(6).
Stubb A.*, Guzmán C.*, Närvä E., Aaron J., Chew T-L., Saari M., Miihkinen M., Jacquemet G, Ivaska J. (2019). Superresolution architecture of pluripotency guarding adhesions. Nature Commun. Oct 18;10(1):4756.
Pietilä M, Sahgal P.1, Peuhu E., Jäntti N., Paatero I., Närvä E., Al-Akhrass H., Lilja J., Georgiadou M., Andersen O., Padzik A., Sihto H., Joensuu H., Blomqvist M., Saarinen I., Boström P., Taimen P. & Ivaska J. SORLA regulates endosomal trafficking and oncogenic fitness of HER2. Nature Commun. 2019 May 28;10(1):2340.
Närvä E, Stubb A, Guzmán C, Blomqvist M, Balboa D, Lerche M, Saari M, Otonkoski T, Ivaska J. (2017) A Strong Contractile Actin Fence and Large Adhesions Direct Human Pluripotent Colony Morphology and Adhesion. Stem Cell Reports Jul 11;9(1):67-76.
Lund RJ, Rahkonen N, Malonzo M, Kauko L, Emani MR, Kivinen V, Närvä E, Kemppainen E, Laiho A, Skottman H, Hovatta O, Rasool O, Nykter M, Lähdesmäki H, Lahesmaa R. RNA Polymerase III Subunit POLR3G Regulates Specific Subsets of PolyA+ and SmallRNA Transcriptomes and Splicing in Human Pluripotent Stem Cells. Stem Cell Reports. 2017 May 9;8(5):1442-1454.
Rahkonen N, Stubb A, Malonzo M, Edelman S, Emani MR, Närvä E, Lähdesmäki H, Ruohola-Baker H, Lahesmaa R, Lund R. Mature Let-7 miRNAs fine tune expression of LIN28B in pluripotent human embryonic stem cells. Stem Cell Res. 2016 Nov;17(3):498-503.
Konki M, Pasumarthy K, Malonzo M, Sainio A, Valensisi C, Söderström M, Emani MR, Stubb A, Närvä E, Ghimire B, Laiho A, Järveläinen H, Lahesmaa R, Lähdesmäki H, Hawkins RD, Lund RJ. Epigenetic Silencing of the Key Antioxidant Enzyme Catalase in Karyotypically Abnormal Human Pluripotent Stem Cells. Sci Rep. 2016 Feb 25;6:22190.
Emani MR*, Närvä E*, Stubb A, Chakroborty D, Viitala M, Rokka A, Rahkonen N, Moulder R, Denessiouk K, Trokovic R, Lund R, Elo LL, Lahesmaa R. (2015) The L1TD1 Protein Interactome Reveals the Importance of Post-transcriptional Regulation in Human Pluripotency. Stem Cell Reports Mar 10;4(3):519-28.
Laurila K, Autio R, Kong L, Närvä E, Hussein S, Otonkoski T, Lahesmaa R, Lähdesmäki H. Integrative genomics and transcriptomics analysis of human embryonic and induced pluripotent stem cells. BioData Min. 2014 Dec 13;7(1):32.
Elisa Närvä*, Juha-Pekka Pursiheimo*, Asta Laiho, Nelly Rahkonen, Maheswara Reddy Emani, Miro Viitala, Kirsti Laurila, Roosa Sahla, Riikka Lund, Harri Lähdesmäki, Panu Jaakkola and Riitta Lahesmaa. Continuous Hypoxic Culturing of Human Embryonic Stem Cells Enhances SSEA-3 and MYC Levels. Plos One 2013. Nov 13;8(11):e78847.
Riikka J. Lund*, Tuomas Nikula*, Nelly Rahkonen, Elisa Närvä, Duncan Baker, Neil Harrison, Peter Andrews, Timo Otonkoski, Riitta Lahesmaa. High-Throughput Karyotyping of Human Pluripotent Stem Cells. Stem Cell Research 2012, Jul 11;9(3):192-195
Kong L.*, Aho K-L.*, Granberg K.*, Lund R.*, Järvenpää L., Seppälä J., Gokhale P., Leinonen K., Hahne L., Mäkelä J., Laurila K., Pukkila H., Närvä E., Yli-Harja O., Andrews P. W., Nykter M., Lahesmaa R., Roos C. & Autio R. (2013) ESTOOLS Data@Hand: human stem cell gene expression resource. Nature Methods Sep;10(9):814-815.
Närvä E.*, Rahkonen N.*, Maheswara R.*, Lund R., Pursiheimo J-P., Nästi J., Autio R., Rasool O., Denessiouk K., Lähdesmäki H., Rao A. and Lahesmaa R. (2012) RNA Binding Protein L1TD1 Interacts with LIN28 via RNA and Is Required for Human Embryonic Stem Cell Self-renewal and Cancer Cell Proliferation. STEM CELLS Mar;30(3):452-60
Hussein S. M.*, Batada N. N.*, Vuoristo S., Ching R. W., Autio R., Närvä E., Ng S., Sourour M., Hämäläinen R., Olsson C., Lundin K., Mikkola M., Trokovic R., Peitz M., Brüstle O., Bazett-Jones D. P., Alitalo K., Lahesmaa R., Nagy A. & Otonkoski T. (2011) Copy number variation and selection during reprogramming to pluripotency. Nature Mar 3;471(7336):58-62.
Närvä E., Autio R., Rahkonen N., Kong L., Harrison N., Kitsberg D., Borghese L., Itskovitz-Eldor J., Rasool O., Dvorak P., Hovatta O., Otonkoski T., Tuuri T., Cui W., Brüstle O., Baker D., Maltby E., Moore H. D., Benvenisty N., Andrews P. W., Yli-Harja O. & Lahesmaa R. (2010) High-resolution DNA analysis of Human Embryonic Stem Cell lines reveals culture-induced copy number changes and loss of heterozygosity. Nature Biotechnology Apr;28(4):371-7.
Rautajoki K., Marttila E., Nyman T. and Lahesmaa R. (2007) IL-4 inhibits Caspase-3 by regulating several proteins in the Fas pathway during the initial stages of human Th2 cell differentiation. Molecular and Cellular Proteomics,Feb;6(2):238-51.
A2 Review article, literature review, systematic review:
Närvä E. Onko syövän kantasolujen kliininen tunnistaminen vieläkin mahdotonta? Lääketieteellinen aikakausikirja DUODECIM. 2023;139(19):1547-53
Conway JRW*, Närvä E*, Taskinen ME*, Ivaska J. (2020) Kinase-Independent Functions of MASTL in Cancer: A New Perspective on MASTL Targeting. Cells. Jul 6;9(7):E1624.
Lund R.*, Närvä E.* & Lahesmaa R. (2012) Genetic and Epigenetic stability of human pluripotent stem cells. Nature Reviews Genetics, Oct;13(10):732-44.